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SNPs Associated With Interferon Beta Response

Which may have predictive value?

Publish date:: October 9, 2015

There may be no association between polymorphisms located in genes related to the type I IFN or TLR pathways or genes encoding neurotransmitter receptors and the clinical response to interferon β (IFN-β), according to a screening study of 830 patients with multiple sclerosis (MS) and an independent validation study of 555 patients with MS. Researchers found:

• 7 single nucleotide polymorphisms (SNPs) were selected from the screening phase:

◊ rs832032

◊ rs6597

◊ rs3747517

◊ rs2277302

◊ rs10958713

◊ rs2834202

◊ rs4422395

• None of these SNPs were significantly associated with IFN-β response when genotyped in an independent cohort of patients.

• Combined analysis revealed 2 polymorphisms associated with IFN-β response:

◊ rs2277302

◊ rs832032

Citation: Bustamante MF, Morcillo-Suárez C, Malhotra S, et al. Pharmacogenomic study in patients with multiple sclerosis. [Published online ahead of print September 24, 2015]. Neurol Neuroimmunol Neuroinflamm. doi: http://dx.doi.org/10.1212/NXI.0000000000000154.

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