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Progranulin Genetic Polymorphisms and Disease Course

What influence do they exert?

Publish date:: October 9, 2015

Progranulin genetic polymorphisms likely influence disease course and relapse recovery in multiple sclerosis (MS), according to a study of genetic variability in 400 patients with MS. Researchers found:

• Incomplete recovery after a relapse is correlated with increased frequency of the rs9897526 A allele (OR, 4.367).

• A more severe disease course is correlated with increased frequency of the rs9897526 A allele (OR, 1.886) and of the rs5848 T allele (OR, 1.580).

• Carriers of the alleles associated with a more severe disease course have significantly lower levels of circulating progranulin.

Citation: Vercellino M, Fenoglio C, Galimberti D, et al. Progranulin genetic polymorphisms influence progression of disability and relapse recovery in multiple sclerosis. [Published online ahead of print October 7, 2015]. Mult Scler. doi: 10.1177/1352458515610646.

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