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Vitamin D-related Factors in MS

Studying the effects in Denmark

Publish date:: October 13, 2015

There is an independent effect by HLA-DRB1*1501, adolescent summer sun habits, and body mass index at the age of 20 on age at onset of MS, according to a study of 1,161 patients with MS. Researchers found:

• Younger age at onset was significantly associated with low exposure to summer sun in adolescence, higher body mass index at age 20 years, and HLA-DRB1*1501 risk allele in both univariate and multivariate analysis.

• No association was found between age at onset and any other SNPs or vitamin-D associated environmental factors.

Citation: Laursen JH, Søndergaard HB, Sørensen PS, Sellebjerg F, Oturai AB. Association between age at onset of multiple sclerosis and vitamin D level–related factors. [Published online ahead of print October 7, 2015]. Neurology. doi: http://dx.doi.org/10.1212/WNL.0000000000002075.

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