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Depression in MS

Correlating differences with limbic system functions

Publish date:: October 13, 2015

Individual differences in depression were significantly associated with altered regional activity and functional connectivity patterns within the limbic system, according to an MRI study of 77 patients with MS and variable levels of depression. Researchers found that depression scores were negatively correlated with the:

• Activity in the subgenual cingulate cortex.

• Functional connectivity between the hippocampus and orbitofrontal cortex as well as the dorsolateral prefrontal cortex.

• Functional connectivity between the amygdala and dorsolateral prefrontal cortex.

Citation: Riccelli R, Passamonti L, Cerasa A, et al. Individual differences in depression are associated with abnormal function of the limbic system in multiple sclerosis patients. [Published online ahead of print October 9, 2015]. Mult Scler. doi: 10.1177/1352458515606987.

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