Key clinical point: Although patients younger that 50 years still constitute a small proportion of overall cases, their disease at presentation is less localized.

Major finding: During 2000-2015, 84.9% of younger patients presented with regional/distant disease, compared with 77.6% of patients aged 50-69 years and 67.8% of patients 70 years and older.

Study details: The data come from a population-based review of 34,443 patients with esophageal adenocarcinoma identified from the Surveillance, Epidemiology, and End Results database for the periods of 1975-1989, 1990-1999, and 2000-2015.

Disclosures: The study was funded in part by the National Cancer Institute and the National Center for Advancing Translational Sciences. Two authors disclosed relationships outside the submitted work, but Dr. Codipilly and the remaining authors had no financial conflicts to disclose.