Family history of psoriasis and psoriatic arthritis (PsA) has impacts on skin phenotypes, musculoskeletal features, and disease severity, according to a recent study. Furthermore, the link between family history of psoriasis/PsA and pustular/plaque phenotypes may point to a different genetic background and pathogenic mechanisms in these subsets. The data from 1,393 patients recruited in the longitudinal, multicenter Psoriatic Arthritis‐International Database (PsArt‐ID) were analyzed. The effects of family history of psoriasis and/or PsA on characteristics of psoriasis and PsA were investigated using logistic regression. Researchers found:

• 444 (31.9%) patients had family history for psoriasis and/or PsA.
• These patients were more frequently women, had earlier onset of psoriasis, more frequent nail disease, enthesitis, deformities, and less frequently achieved minimal disease activity (MDA).
• 335/444 patients only had psoriasis in their family, 74 had PsA, and 35 patients were not clear and therefore excluded from further analysis.
• In multivariate analysis, family history of psoriasis was associated with younger onset of psoriasis and presence of enthesitis, whereas family history of PsA was associated with lower risk of plaque psoriasis and higher risk for deformities.