Key clinical point: Patients with rheumatoid arthritis (RA) were at an increased risk for Parkinson disease (PD), and patients with seropositive RA had an augmented risk for PD.
Major finding: The risk for PD was 1.74-fold higher in patients with RA vs control individuals without RA (adjusted hazard ratio [aHR] 1.74; 95% CI 1.52-1.99), 1.95-fold higher in patients with seropositive RA vs control individuals without RA (aHR 1.95; 95% CI 1.68-2.26), and 1.61-fold higher in patients with seropositive vs seronegative RA (aHR 1.61; 95% CI 1.20-2.16).
Study details: Findings are from a retrospective cohort study including 54,680 patients with RA (seropositive RA n = 39,010, and seronegative RA n = 15,670) and 273,400 age- and sex-matched control individuals without RA.
Disclosures: This study did not declare the source of funding or any conflicts of interest.
Source: Kang J et al. Rheumatoid arthritis and risk of Parkinson disease in Korea. JAMA Neurol. 2023 (May 1). Doi: 10.1001/jamaneurol.2023.0932