When compared with sequential vaccination, the concomitant administration of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) and influence vaccines during pregnancy was not associated with a higher risk of medically attended adverse acute outcomes or birth outcomes, according to a study of 36,844 pregnancies in which Tdap and influenza vaccines were administered. The vaccines were administered concomitantly in 23% or pregnancies and sequentially in 77% of pregnancies and results determined:

• Acute adverse events after vaccination were rare.

• There was no statistically significant increased risk of fever or nay medically attended acute adverse events in pregnant women vaccinated concomitantly compared with sequentially.

• There were no differences in preterm delivery, low birth weight, or small for gestational age neonates between women vaccinated concomitantly compared with sequentially in pregnancy at 20 weeks of gestation or greater during periods of influenza vaccine administration.

Citation: Sukumaran L, McCarthy NL, Kharbanda EO, et al. Safety of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis and influenza vaccinations in pregnancy. [Published online ahead of print October 5, 2015].