Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Breast Density Alone Should Not Prompt Supplemental Imaging Discussions
Key clinical point: Breast density paired with 5-year risk is more efficient than density alone in prompting supplemental imaging discussions.
Major finding: In a hypothetical cohort of 100,000 women, supplemental imaging for all 47,012 women with dense breasts would mean a ratio of 1,866 imaging discussions per potential advanced breast cancer prevented.
Study details: A prospective cohort study of 638,856 women aged 40 to 74 years who had mammograms taken between Jan. 3, 2005, and Dec. 31, 2014.
Disclosures: The study was funded by the Patient-Centered Outcomes Research Institute, the Breast Cancer Surveillance Consortium, the National Cancer Institute, the Agency for Health Research and Quality, and the Lake Champlain Cancer Research Organization. The authors reported several potential conflicts of interest, including being members of various working groups, advisory boards, committees, task forces, and panels.
Kerlikowske K et al. JAMA Intern Med. 2019 Jul 1. doi:10.1001/jamainternmed.2019.1758.