For individuals with multiple sclerosis (MS), engaging in self-compassion may provide a strategy to cope with debilitating conditions and reframe perceptions of their health, according to a recent study. Additionally, increasing resilience may help individuals overcome stressful and traumatic events and experience quality of life with disability. Self-compassion and resilience are both modifiable constructs that can be targeted by programs seeking to improve overall wellness. 259 adults with MS—from MS advocacy, support, exercise, and education groups around the US—participated in the study. Participants' self-compassion, health-related quality of life (HRQoL), and resilience were assessed using self-report measures. A simple mediation analysis was conducted to examine the relationships between the independent variable, self-compassion, the depended variable, HRQoL, and the mediating variable, resilience. Researchers found that there was a significant direct effect between self-compassion and health-related quality of life (β=0.49), as well as an indirect relationship through resilience (β=0.18).