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Bilateral DBS May Improve Gait in PD
Parkinsonism Relat Disord; ePub 2017 Feb 23; Chenji, et al
Contrary to expectations from earlier studies of dual-task motor performance, bilateral subthalamic deep brain stimulation may assist in maintaining temporal and spatial gait performance in Parkinson disease under cognitive dual-task conditions, a recent study found. Gait kinematics of 17 patients with advanced Parkinson disease who had undergone bilateral, subthalamic, deep brain stimulation were examined off medication under 3 stimulation states (bilateral, unilateral left, unilateral right) with and without a cognitive challenge, using an instrumented walkway system. Researchers found:
- Consistent with earlier studies, gait performance declined for all 6 measured parameters under cognitive dual-task conditions, independent of stimulation state.
- However, bilateral stimulation produced greater improvements in step length and double-limb support time than unilateral stimulation, and achieved similar performance for other gait parameters.
Chenji G, Wright ML, Chou KL, Seidler RD, Patil PG. Parkinsonian gait improves with bilateral subthalamic nucleus deep brain stimulation during cognitive multi-tasking. [Published online ahead of print February 23, 2017]. Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2017.02.028.