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Bilateral DBS May Improve Gait in PD

Parkinsonism Relat Disord; ePub 2017 Feb 23; Chenji, et al

Contrary to expectations from earlier studies of dual-task motor performance, bilateral subthalamic deep brain stimulation may assist in maintaining temporal and spatial gait performance in Parkinson disease under cognitive dual-task conditions, a recent study found. Gait kinematics of 17 patients with advanced Parkinson disease who had undergone bilateral, subthalamic, deep brain stimulation were examined off medication under 3 stimulation states (bilateral, unilateral left, unilateral right) with and without a cognitive challenge, using an instrumented walkway system. Researchers found:

  • Consistent with earlier studies, gait performance declined for all 6 measured parameters under cognitive dual-task conditions, independent of stimulation state.
  • However, bilateral stimulation produced greater improvements in step length and double-limb support time than unilateral stimulation, and achieved similar performance for other gait parameters.

Citation:

Chenji G, Wright ML, Chou KL, Seidler RD, Patil PG. Parkinsonian gait improves with bilateral subthalamic nucleus deep brain stimulation during cognitive multi-tasking. [Published online ahead of print February 23, 2017]. Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2017.02.028.