Clinical Inquiries
Clinical Inquiries
Does metformin prevent diabetes in at-risk adults?
EVIDENCE-BASED ANSWER: Yes. Metformin therapy reduces the risk of developing diabetes for adults with one or more risk factors for at least 5...
Clinical Inquiries
What is the best initial treatment for venous stasis ulcers?
EVIDENCE-BASED ANSWER: THE MAINSTAY OF INITIAL TREATMENT of venous stasis ulcers is compression therapy (strength of recommendation [SOR]: A,...
Clinical Inquiries
How best to treat agitation in patients with irreversible dementia?
EVIDENCE-BASED ANSWER: Atypical antipsychotics modestly reduce agitation compared with placebo but have significant adverse effects (strength of...
Clinical Inquiries
What is the best treatment for plant-induced contact dermatitis?
EVIDENCE-BASED ANSWER: IT’S UNCLEAR which treatment is best, because there have been no head-to-head comparisons of treatments for Rhus (plant-...
Clinical Inquiries
How can pregnant women safely relieve low-back pain?
EVIDENCE-BASED ANSWER: ACETAMINOPHEN IS SAFE for use in pregnancy but lacks evidence of efficacy (strength of recommendation [SOR]: C, usual...
Clinical Inquiries
How much does weight loss affect hypertension?
EVIDENCE-BASED ANSWER: WEIGHT LOSS OF 4 KG by diet reduces systolic and diastolic blood pressure (BP) by 4.5 and 3.2 mm Hg, respectively (SOR: A,...
Clinical Inquiries
Should you test or treat pregnant women with a history of pregnancy-related VTE?
EVIDENCE-BASED ANSWER: YOU PROBABLY SHOULDN’T TEST, although you may want to treat your patient with low-molecular-weight heparin (LMWH).
Clinical Inquiries
Should preparticipation physicals for school-aged athletes include routine EKGs?
EVIDENCE-BASED ANSWER: PROBABLY NOT. Although some European and international experts recommend that all athletes undergo preparticipation...
Clinical Inquiries
Which oral antifungal works best for toenail onychomycosis?
EVIDENCE-BASED ANSWER: TERBINAFINE, 250 mg daily for 12 to 16 weeks, produces higher clinical cure rates than either pulsed-dose itraconazole or...
Clinical Inquiries
Which treatments help women with reduced libido?
EVIDENCE-BASED ANSWER: SEVERAL TREATMENTS produce modest, but statistically significant, clinical increases in sexual desire and function in women...
Clinical Inquiries
Do patients with type 2 diabetes who aren’t taking insulin benefit from self-monitoring blood glucose?
EVIDENCE-BASED ANSWER: YES, UNDER SOME CIRCUMSTANCES. Patients with type 2 diabetes who aren’t on insulin and perform self- monitoring of blood...