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Nab-paclitaxel marginally superior to dacarbazine for metastatic melanoma
Key clinical point: Nab-pacilitaxel had significantly longer PFS than dacarbazine in chemotherapy-naive patients with metastatic melanoma. Major...
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Noninvasive ventilation no better than oxygen alone in immunocompromised ICU patients
Key clinical point: Noninvasive ventilation, compared with oxygen therapy alone, did not reduce 28-day mortality among immunocompromised patients...
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Aberrant miRNA levels may reflect progression to multiple myeloma
Key clinical point: Low levels of specific miRNAs in peripheral blood may reflect disease progression from MGUS and smoldering disease to multiple...
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Routine imaging for diffuse large B-cell lymphoma offers no survival benefit
“An imaging-based follow-up strategy does not improve postremission [overall survival] for DLBCL,” wrote Dr. Tarec Christoffer El-Galaly, of...
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Lung adenocarcinoma can harbor both ALK fusions and EGFR driver mutations
Key clinical point: Tumor cells within the same primary tumor were found to harbor both ALK fusions and EGFR driver mutations. Major finding: In...
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Adjuvant hormone therapy may improve survival in epithelial ovarian cancer
Patients with epithelial ovarian cancer who were randomly assigned to receive adjuvant hormone therapy (AHT) had significantly better overall...
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ASCO: Racial disparity in HER2+ breast cancer survival subsided after trastuzumab approval
Key clinical point: The well-documented disparity in survival between black and white patients with HER2+ breast cancer was not observed during a...
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ASCO: Overall survival similar regardless of distant relapse site in breast cancer
Key clinical point: In patients with metastatic breast cancer, initial distant relapse site had little influence on overall survival rates. Major...
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Histologic information can’t replace recurrence score
Key clinical point: A combination of three histologic variables (tumor size, grade, and cellular proliferation marker Ki67) failed to accurately...
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Topical resiquimod effective for early-stage cutaneous T-cell lymphoma
Key clinical point: Topical resiquimod was effective and well tolerated in patients with early-stage cutaneous T-cell lymphoma (CTCL).
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No evidence for CLL transmission via blood transfusion
Key clinical point: There is no evidence for higher risk of chronic lymphocytic leukemia (CLL) among recipients of blood products from donors who...
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CLL exosomes promote stromal cell transition into cancer-associated fibroblasts
Key clinical point: Exosomes derived from chronic lymphocytic leukemia (CLL) cells induce stromal cell transition to cancer-associated fibroblasts...
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Lenalidomide, thalidomide similar when combined with melphalan and prednisone for multiple myeloma
Key clinical point: In elderly patients with multiple myeloma, outcomes were similar with melphalan and prednisone combined with either...
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Noncanonical Wnt signaling implicated in antiandrogen-resistant prostate cancer
Key clinical point: Noncanonical Wnt signaling was significantly enriched in single circulating tumor cells (CTCs) from patients resistant to the...
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Radiation field optimization may preserve salivary gland function
Key clinical point: Optimized radiotherapy that spares salivary gland stem cells during treatment for head and neck cancer may preserve patients’...