News
Thrombocytopenia signals multiorgan system failure in acute liver failure
Key clinical point: In patients with acute liver failure (ALF), decreasing platelet counts were associated with systemic inflammation and greater...
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SIRT plus FOLFOX chemo for mCRC improved progression-free survival in liver only
Key clinical point: Selective internal radiation therapy (SIRT) combined with FOLFOX-based chemotherapy in patients with metastatic colorectal...
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Muscle loss during chemotherapy predicts poor survival in metastatic colorectal cancer
Key clinical point: Patients with metastatic colorectal cancer (mCRC) whose muscle mass dropped by 9% or more during chemotherapy had...
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Low serum vitamin D may signal more aggressive prostate cancer
Key clinical point: Serum 25-hydroxyvitamin D (25-OH D) deficiency was associated with greater risk for adverse pathology in men with localized...
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Ponatinib effective in chronic phase CML regardless of baseline mutation status
Key clinical point: Baseline mutation status had little impact on ponatinib response, and no single or compound mutation was a major driver of...
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Panobinostat plus bortezomib and dexamethasone improved outcomes in previously treated multiple myeloma
Key clinical point: Panobinostat plus bortezomib and dexamethasone improved outcomes in patients with previously treated multiple myeloma,...
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Breast cancer patients at increased risk of colorectal cancer
Key clinical point: Colorectal cancer risk was significantly increased in patients previously diagnosed with breast cancer. Major finding:...
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Nanoparticles deliver Aurora kinase inhibitor with increased safety and efficacy
Key clinical point: Aurora B kinase inhibitor nanoparticles displayed accumulation and retention in tumors with improved efficacy and minimal bone...
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Lysolipid antigens prominent in MGUS and myeloma
Key clinical point: In patients with Gaucher disease and in nearly one-third of patients with MGUS or myeloma, clonal immunoglobulins reacted with...
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Defibrotide offers benefit for severe veno-occlusive disease and multiorgan failure
Key clinical point: Defibrotide improved survival at 100 days after hematopoietic stem cell transplantation (HSCT) in patients with hepatic veno-...
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Resources limit availability of bone marrow transplants
Key clinical point: In regions with limited resources, peripheral blood stem cells were used more frequently than bone marrow in hematopoietic...
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Early mortality predicted by age and poor performance status in patients with colon cancer
Key clinical point: Among patients with colon cancer enrolled in phase III trials for adjuvant therapy, mortality within 6 months of random...
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Cola enhances absorption of erlotinib in NSCLC
Key clinical point: Taking oral erlotinib with cola significantly increased the drug’s bioavailability in patients concomitantly taking the acid-...
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High-dose interferon offered no survival benefit in patients with melanoma and a single tumor–positive sentinel lymph node
Key clinical point: Adjuvant high-dose interferon (HDI) did not improve survival in patients with a single tumor–positive sentinel lymph node (SLN...
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Patient prognostic score may lessen DCIS overtreatment
Key clinical point: A recurrence risk score based on clinicopathologic features of ductal carcinoma in situ (DCIS) was associated with survival...