It is possible that insulin resistance within the brain doesn’t correlate with peripheral measures of insulin resistance, so further study of this question is warranted. Moreover, AD is a complex process that involves more than just beta-amyloid accumulation, so "long-term therapeutic trials [also] are important to elucidate this issue," the investigators added.
This study was supported by the National Institute on Aging and the Burroughs Wellcome Fund for Translational Research. No financial conflicts of interest were reported.