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Dementia Incidence Trends in Birth Cohort Analysis

JAMA Neurol; ePub 2017 Sep 5; Derby, et al

A recent study that examined trends in dementia and concomitant trends in cardiovascular comorbidities among individuals aged ≥70 years enrolled in the Einstein Aging Study confirmed decreasing incidences of dementia in this population. In this birth cohort analysis of all-cause dementia incidence in persons enrolled in the Einstein Aging Study between 1993 and 2015, researchers studied a sample of 1,348 older adults from Bronx County, NY, without dementia at enrollment and at least 1 annual follow-up. They found:

  • Among total individuals (830 [61.6%] female; 915 [67.9%] non-Hispanic white), 150 incident dementia cases developed during 5,932 person-years (mean [SD] follow-up, 4.4 [3.4] years).
  • Dementia incidence decreased in successive birth cohorts.
  • Incidence per 100 person-years was 5.09 in birth cohorts before 1920, 3.11 in the 1920 through 1924 birth cohorts, 1.73 in the 1925 through 1929 birth cohorts, and 0.23 in cohorts born after 1929.
  • Change point analyses identified a significant decrease in dementia incidence among those born after July 1929.
  • Prevalence of stroke and myocardial infarction decreased across successive birth cohorts, whereas diabetes prevalence increased.

Citation:

Derby CA, Katz MJ, Lipton RB, Hall CB. Trends in dementia incidence in a birth cohort analysis of the Einstein Aging Study. [Published online ahead of print September 5, 2017]. JAMA Neurol. doi:10.1001/jamaneurol.2017.1964.