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The Pathogenesis of Lacunar Stroke

Assessing associations in subtypes

Publish date:: December 22, 2015

The oxidative phosphorylation (OXPHOS) pathway is implicated in the pathogenesis of lacunar stroke, an association specific to patients with the multiple lacunar infarcts/leukoaraiosis (MLI/LA) subtype. This according to a study of 1,012 patients with MRI-confirmed lacunar stroke and 964 age-matched controls. Researchers found:

• A specific association with strong evidence of enrichment exists in the top 1% of genes in the MLI/LA subtype, but not in the isolated lacunar infarcts subtype.

• Genes in the top percentile for the all lacunar stroke analysis were not significantly enriched.

Citation: Traylor M, Anderson CD, Hurford R, Bevan S, Markus HS. Oxidative phosphorylation and lacunar stroke: Genome-wide enrichment analysis of common variants. [Published online ahead of print December 16, 2015]. Neurology. doi: 10.1212/WNL.0000000000002260.

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