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Genetic Contributions to Inflammatory and Hemostatic Biomarkers
Studying their contribution in a stroke population
There is a genetic contribution to inflammatory and hemostatic biomarkers in a stroke population, according to a study of 3,680 adults with nondisabling cerebral infarction. Researchers found:
• An association was detected between C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) and circulating CRP levels in 2,100 study participants, with rs2592902 the most associated SNP.
• There is a novel association for CRP level in the AKR1D1 locus (rs2589998) that also is an expression quantitative trait locus for CRP gene expression.
• Previously identified associations of fibrinogen with SNPs in the FGB and LEPR loci were replicated.
• CRP-associated SNPs and CRP levels were significantly associated with risk of ischemic stroke and recurrent stroke in this cohort as well as specific stroke subtypes in the METASTROKE Collaboration.
• Fibrinogen levels but not fibrinogen-associated SNPs were also associated with recurrent stroke in this cohort.
Citation: Williams SR, Hsu FC, Keene KL, et al. Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. [Published online ahead of print December 30, 2015]. Neurology. doi: 10.1212/WNL.0000000000002319.