Chordoma patients, caregivers, and health care professionals have a new resource to aid in their fight against chordoma, with the publication of the first detailed, multidisciplinary treatment guidelines in the journal The Lancet Oncology. These recommendations are the result of a year-long effort of more than 40 international chordoma experts led by the Istituto Nazionale dei Tumori in Milan (the National Cancer Institute of Italy) in partnership with the Chordoma Foundation. They reflect expert consensus on best practices for the comprehensive management of chordoma in all locations of the body in multiple settings and scenarios.