Alzheimer's & Cognition
30th Anniversary
From failure to hope: Tracking the changing landscape of Alzheimer’s therapies
The Alzheimer's Drug Development Pipeline report, updated annually since 2016, classifies Alzheimer's therapies by their targets, their mechanisms...
Latest News
High and low HDL cholesterol levels linked to dementia risk
There was no significant association between LDL cholesterol and dementia risk.
Literature Review
Proton pump inhibitors linked to increased dementia risk
“The association between PPI use and dementia was unambiguously largest among the youngest cases of dementia.”
Latest News
History of depression, stress tied to Alzheimer’s, MCI risk
“Future studies should examine the possibility that symptoms of depression and/or chronic stress could be prodromal symptoms of dementia,” the...
Commentary
Do new Alzheimer’s drugs get us closer to solving the Alzheimer’s disease riddle?
It’s increasingly clear to this observer that cognitive reserve is synonymous with organic brain health.
From the Journals
Loneliness tied to increased risk for Parkinson’s disease
The association between loneliness and incident PD was not moderated by sex, age, or polygenetic risk score.
Commentary
Multivitamins and dementia: Untangling the COSMOS study web
When you get a positive result in your research, it’s always exciting. But when a slew of studies that came before you are negative, you aren’t...
Literature Review
Unique twin study sheds new light on TBI and risk of cognitive decline
“We know that TBI increases the risk of dementia in later life, but we haven’t known if TBI affects cognitive function, causes cognitive decline...
From the Journals
AHA reviews impact of aggressive LDL lowering on the brain
The risk for hemorrhagic stroke associated with statin therapy in patients without a history of cerebrovascular disease is “small and consistently...
Literature Review
How does lecanemab work in Alzheimer’s?
“In our study, we looked at lecanemab and found it can block the activation of the contact system, which could be one of the reasons that it works...
Literature Review
Sedentary lifestyle tied to increased dementia risk
Dementia risk was elevated whether participants were sedentary for 10 uninterrupted hours or multiple sedentary periods that totaled 10 hours over...