Melanoma
News
The push for smaller, smarter cancer trials
News
Nivolumab extends survival in advanced melanoma
Major finding: The PD-1 receptor inhibitor nivolumab effected sustained response in 31% of those who took it for advanced melanoma. Data source: A...
News
Vemurafenib improved survival in BRAF mutation–positive metastatic melanoma
Major finding: The median overall survival was 13.6 months for patients receiving vemurafenib compared with 9.7 months for patients receiving...
News
Aggressive secondary squamous carcinoma appeared during BRAF inhibitor targeted therapy
Major finding: A woman undergoing BRAF inhibitor targeted therapy for advanced melanoma has presented with invasive spindle cell squamous...
Community Translations
Dabrafenib in advanced melanoma with BRAF V600E mutation
Dabrafenib was recently approved by the US Food and Drug Administration for treatment of unresectable or metastatic melanoma with BRAF V600E...
News
Final results validate sentinel-node biopsy for melanoma
Major finding: Among patients with nodal metastases, disease-free survival was increased by a factor of 3.2, distant-disease-free survival was...
Reviews
Current options and future directions in the systemic treatment of metastatic melanoma
Systemic treatment options for metastatic melanoma have historically been limited, with conventional cytotoxic chemotherapies demonstrating only...
News
VEGF level may predict response to ipilimumab
Major Finding: 41% of 90 patients with low serum VEGF showed clinical benefit with ipilimumab, compared with 23% of the 69 patients with a high...
News
IBD linked to increased risk of certain cancers
Major finding: In a population-based cohort study, patients with inflammatory bowel disease (IBD) were found to be at increased risk for...
News
Poor accrual halts one in five cancer clinical trials
Major finding: About 20% of cancer clinical trials fail to reach completion for reasons unrelated to efficacy or toxicity, and the most common...