Immuno-oncology
Conference Coverage
CAR T-cell therapy advances in CLL
ORLANDO – The safety and clinical activity of the CD19-directed CAR T-cell agent justifies moving forward with phase 2 investigation, researchers...
Conference Coverage
Inhibitor appears to strengthen anti-BCMA CAR T cells in myeloma patients
ORLANDO – All 10 patients responded to anti-BCMA CAR T-cell therapy, including 3 patients who had previously failed BCMA-directed therapy.
Conference Coverage
Survival data reported from largest CAR T trial in B-cell lymphoma
ORLANDO – Progression-free survival results were best among complete responders and patients with primary mediastinal large B-cell lymphoma or...
Conference Coverage
‘Real-world’ data show CAR T therapies are cost effective
ORLANDO – An analysis of Medicare claims data found that treatment with CAR T-cell therapy was associated with fewer hospitalizations and shorter...
Conference Coverage
An off-the-shelf drug to rival CAR T cells: ‘very exciting’
ORLANDO – Mosunetuzumab is a bispecific antibody that targets both CD3 and CD20. It was tested in a phase 1/1b trial among patients with relapsed/...
Conference Coverage
Pembrolizumab plus chemo boosts pCR rate in TNBC
SAN ANTONIO – The immune checkpoint inhibitor added to standard chemotherapy increased the likelihood of a pathologic complete remission,...
Conference Coverage
Off-the-shelf cellular therapy shows promise in the lab
ORLANDO – Findings from this preclinical research support moving forward with a phase 1 study of the therapy, as monotherapy or combined with...
Conference Coverage
Bispecific CAR T-cells yield high response rate in relapsed/refractory myeloma
ORLANDO – Duration of response, manageable safety support further investigation of dual-targeted strategy, according to investigator.
Conference Coverage
High complete response rate seen with novel CAR-T for myeloma
ORLANDO – A CAR T product targeting B-cell maturation antigen, one of several in development, was associated with a 100% overall response rate.
From the Journals
Patient-reported outcomes support first-line pembrolizumab for NSCLC
At week 18 in KEYNOTE-407, more patients in the pembrolizumab plus chemotherapy group reported improvements in health-related quality of life,...
From the Journals
Sequential CRT, immunotherapy nets high PFS in node-positive cervical cancer
More than four in five patients were alive and free of disease progression a year after receiving chemoradiotherapy followed by ipilimumab, and...