Cythemias
News
Breast cancer drug could treat MPNs, AML
Credit: CDC Tamoxifen, a drug used to treat breast cancer, may be effective against myeloproliferative neoplasms (MPNs) and acute myeloid...
News
FDA approves first drug for polycythemia vera
Credit: AFIP The US Food and Drug Administration (FDA) has expanded the approved use of ruxolitinib (Jakafi) to include treatment of patients...
News
DNA finding has implications for MPNs
Credit: NIGMS A new study suggests the timing of DNA replication—including where the origin points are and in what order DNA segments are copied—...
News
Hematology drugs on the fast track
Credit: Bill Branson The US Food and Drug Administration (FDA) has granted fast track designation to two hematology drugs: the monoclonal...
News
FDA lifts clinical hold on imetelstat
The hold, which was placed in March, suspended a phase 2 study of imetelstat in patients with essential thrombocythemia (ET) or polycythemia vera...
News
Exome sequencing shows potential as diagnostic tool
Credit: Graham Colm In a large study, whole-exome sequencing provided 25% of patients with a diagnosis related to a known genetic disease, giving...
News
A single cell can cause MPNs
Credit: Aaron Logan Scientists have found that a single cell containing the JAK2-V617F mutation can cause myeloproliferative neoplasms (MPNs) in...
News
Genes aid classification of polycythemia vera
Credit: AFIP New research has revealed a molecular method for classifying patients with polycythemia vera (PV). Investigators identified 102...
News
Drug gets fast track designation for MF
Credit: Peter Anderson The US Food and Drug Administration (FDA) is expediting its review of pacritinib, a tyrosine kinase inhibitor with...
News
Biochemical cascade can lead to MPNs
Credit: Indiana University Preclinical research has revealed a cascade of molecular events in the bone marrow that produce high levels of...
Conference Coverage
Inhibitor shows promise for hematologic disorders
Photo courtesy of EHA MILAN—The IDH2 inhibitor AG-221 is well-tolerated and exhibits durable clinical activity in patients with hematologic...