Deprecated function: Return type of DatabaseStatementBase::execute($args = [], $options = []) should either be compatible with PDOStatement::execute(?array $params = null): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2246 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
Deprecated function: Return type of DatabaseStatementEmpty::current() should either be compatible with Iterator::current(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2348 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
Deprecated function: Return type of DatabaseStatementEmpty::next() should either be compatible with Iterator::next(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2348 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
Deprecated function: Return type of DatabaseStatementEmpty::key() should either be compatible with Iterator::key(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2348 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
Deprecated function: Return type of DatabaseStatementEmpty::valid() should either be compatible with Iterator::valid(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2348 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
Deprecated function: Return type of DatabaseStatementEmpty::rewind() should either be compatible with Iterator::rewind(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2348 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
Applied Evidence
Evaluating idiopathic venous thromboembolism: What is necessary, what is not
We would not recommend discontinuing anticoagulation to conduct testing for these uncommon defects once it has been initiated following an acute thrombotic event. Rather, testing should be pursued once the planned course of anticoagulation with warfarin has been completed (for example, 6 to 9 months).
Other inherited thrombophilic disorders include heparin cofactor II deficiency, plasminogen deficiency, dysfibrinogenemia, factor XII deficiency, and increased factor VIII coagulant activity. These disorders are rare and their clinical importance remains unclear. Testing for these disorders, if desired, is best conducted in consultation with a hematologist or coagulation specialist.
Corresponding author Charles F.S. Locke, MD, Johns Hopkins Community Physicians, 2360 W. Joppa Rd., Baltimore, MD 21093. E-mail: clocke@jhmi.edu.