Dermpath Diagnosis

Pretibial Myxedema
Pretibial myxedema is a cutaneous mucinosis associated with thyroid dysfunction. The differential diagnosis includes nephrogenic systemic fibrosis...
Anthony J. Kruse, BA; Claudia I. Vidal, MD, PhD
From the Department of Dermatology, Saint Louis University, Missouri.
The authors report no conflict of interest.
Correspondence: Claudia I. Vidal, MD, PhD, Department of Dermatology, Anheuser-Busch Eye Institute, 4th Floor, Room 402,
1755 S Grand Blvd, St. Louis, MO 63104 (cvidal1@slu.edu).
Figure 4. Erythema induratum is characterized by a lobular panniculitis (A and B)(both H&E, original magnifications ×40 and ×200). Vascular changes (arrowhead) are present in a majority of cases with endothelial swelling and extravasation of erythrocytes (C)(H&E, original magnification ×400). |
Figure 5. Neutrophilic panniculitis that can be seen in α1-antitrypsin deficiency panniculitis (H&E, original magnification ×400). |
Figure 6. Infectious panniculitis secondary to Cryptococcus showing a granulomatous reaction in the subcutis (A)(H&E, original magnification ×40). Closer inspection shows a dense infiltrate of chronic inflammatory cells including numerous histiocytes and multinucleated giant cells. Some of the giant cells contain refractile organisms (arrowhead)(B)(H&E, original magnification ×400). Mucicarmine histochemical stain highlights the capsule of the organism (C)(original magnification ×400). |
Acknowledgment
The authors would like to thank Drake Poeschl, MD, St. Louis, Missouri, for proofreading the manuscript.
Pretibial myxedema is a cutaneous mucinosis associated with thyroid dysfunction. The differential diagnosis includes nephrogenic systemic fibrosis...
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