The study was funded by China’s public welfare industry of health.
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“Several key clinical messages can be gained from the study by Patel et al.,” wrote Dr. Jeremy R. Beitler, Dr. Robert L. Owens, and Dr. Atul Malhotra, in an accompanying editorial (JAMA 2016 Jun; 315:2401-3.).
“The helmet interface has unique advantages and disadvantages that may influence efficacy of noninvasive positive pressure ventilation (NIV) depending on patient and disease characteristics,” they said. “External validation of the findings by Patel et al. and clarification of appropriate eligibility criteria, optimal ventilator settings, and potential mechanisms of effect are needed before clinicians could consider an expanded role for helmet NIV in routine management. Regardless, it is increasingly clear that there may be an important albeit underinvestigated role for some form of high-level noninvasive respiratory support to prevent intubation, and perhaps mortality, in acute hypoxemic respiratory failure,” they noted.
“In future studies, reporting of interruptions to wearing the prescribed NIV interface continuously, leak severity, biomarkers of lung injury, and sedative administration would help delineate potential mechanisms [of action],” they added.
Dr. Beitler, Dr. Owens, and Dr. Malhotra are all affiliated with the division of pulmonary and critical care medicine at the University of California, San Diego. They had no financial conflicts to disclose.
FROM JAMA