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Racial, age disparities confirmed in triple-negative breast cancer
In a cohort of more than a million breast cancer cases, likelihood of having a tumor with the TNBC phenotype was roughly twice as high for black...
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Vemurafenib has durable activity in NSCLC harboring BRAF V600 mutations
More than a third of patients had a complete or partial response to monotherapy with the oral BRAF(V600E) kinase inhibitor, and median overall...
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Multigene panel sequencing is moderately cost-effective in NSCLC
Compared with a single-marker approach, a multigene panel approach had an incremental cost-effectiveness ratio of about $148,000 per life-year...
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EHR default order slashes unnecessary imaging during palliative RT
After implementation of the default order specifying no daily imaging during palliative radiation therapy, patients were 63% less likely to...
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Specific prednisone regimen safer than others when used with abiraterone for mCR prostate cancer
Prednisone, 5 mg, twice daily, gave the most favorable overall safety profile when with regard to avoiding mineralocorticoid excess and long-term...
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Liquid biopsy assays found sensitive for NSCLC EGFR mutations
Two liquid biopsy assays performed well at detecting EGFR mutations in plasma-derived cell-free DNA from patients with NSCLC, possibly...
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Immunotherapy-treated NSCLC: Adverse impact of steroids driven by palliative indications
A new analysis suggests use of steroids for cancer-related palliation in patients with poor prognosis largely explains their association with...
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Niraparib-pembrolizumab combo finds niche in breast, ovarian cancers
The combination had good antitumor activity, as well as good safety and tolerability, in patients with advanced TNBC or ovarian carcinoma who were...
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Neoadjuvant-adjuvant erlotinib shows promise in locally advanced NSCLC
The EMERGING trial failed to meet its primary endpoint of higher OR but did meet the secondary endpoint of longer PFS.
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Study raises questions about PPS exemption for cancer centers
Hospitals affiliated with PPS-exempt cancer centers and hospitals affiliated with NCI cancer centers were similar on most metrics.
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Low-dose CT lung cancer screening nets payoff in community setting too
A survey of 165 lung cancer screening centers suggests low-dose CT screening is being effectively implemented in community practices, replicating...
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Syncope during pregnancy increases risk for poor outcomes
Syncope during pregnancy is not as benign as once thought, carrying higher risks of preterm birth, congenital anomalies, and postpartum cardiac...
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Use of Oncotype DX to tailor breast cancer treatment likely to reduce costs
In the wake of the TAILORx trial, routine use of Oncotype DX in women with early breast cancer is expected to increase testing costs but decrease...
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Post-treatment persistence of oral HPV in HNSCC predicts recurrence, death
Patients who still had detectable oral HPV DNA after primary treatment had a more than tripling of risk of recurrence-free survival events and a...
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Oropharynx cancer burden is shifting to older men
Increasing incidence of oropharynx cancer in individuals born after 1955 has slowed, whereas incidence continues to rise among individuals born...