Article
Conservative oxygen therapy in the ICU reduces mortality
A protocol of conservative oxygen therapy is superior to conventional, more liberal oxygen therapy when it comes to minimizing the risk of death...
News
DNA methylation rises sharply at progression of Ph+ CML
Key clinical point: Increases in DNA methylation occur at progression of Ph+ CML; this realization may enable new therapeutic targets. Major...
News
Data point to optimal window for endoscopy in sicker patients with peptic ulcer bleeding
The timing of endoscopy may make the difference between life and death in sicker patients with peptic ulcer bleeding, according to an analysis of...
News
ESR1 mutations found prognostic but not predictive in metastatic breast cancer
Key clinical point: An ESR1 mutation in circulating DNA after progression on endocrine therapy was a marker for poor prognosis but did not predict...
News
New data shed light on impact of resecting the primary tumor in stage IV breast cancer
Key clinical point: Resecting the primary tumor up front had a survival benefit, whereas resecting it after a response to systemic therapy did not...
News
Pembrolizumab-ipilimumab combo is highly active in advanced melanoma
Key clinical point: Dual immune checkpoint blockade with pembrolizumab and ipilimumab is efficacious in advanced melanoma. Major finding: The...
News
Safety of sentinel node dissection alone holds up a decade out
Key clinical point: In women with clinical early-stage breast cancer who have a positive sentinel node and undergo breast-conserving therapy,...
News
Opioid overdose epidemic now felt in the ICU
SAN FRANCISCO – The opioid overdose crisis in the United States is now plainly evident in intensive care units (ICUs), finds a study of hospitals...
News
Dual immune checkpoint blockade found durable in melanoma
Key clinical point: Nivolumab-ipilimumab combination therapy and nivolumab monotherapy are more efficacious than ipilimumab monotherapy when used...
News
Staffing, work environment drive VAP risk in the ICU
Key clinical point: The impact of nurse work environment on risk of VAP in the ICU depends on the unit’s physician staffing model. Major finding:...
News
Resident transitions increase inpatients’ risk of death
SAN FRANCISCO – Hospitalized patients who have a change in the medical residents responsible for their care are more likely to die, finds a...
News
Delaying renal replacement therapy in critically ill patients has advantages
Key clinical point: Delaying initiation of renal replacement therapy in critically ill patients with kidney injury appears safe and beneficial....
News
Edaravone slows progression of ALS when started early on
Key clinical point: When added to standard of care, edaravone slows loss of function in patients with early-stage ALS. Major finding: Compared...
News
Real-world data favor dimethyl fumarate, fingolimod for MS
Key clinical point: In real-world care, dimethyl fumarate and fingolimod appear more effective than other disease-modifying therapies for MS....