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    • Deprecated function: Return type of DatabaseStatementBase::execute($args = [], $options = []) should either be compatible with PDOStatement::execute(?array $params = null): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2246 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
    • Deprecated function: Return type of DatabaseStatementEmpty::current() should either be compatible with Iterator::current(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2348 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
    • Deprecated function: Return type of DatabaseStatementEmpty::next() should either be compatible with Iterator::next(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2348 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
    • Deprecated function: Return type of DatabaseStatementEmpty::key() should either be compatible with Iterator::key(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2348 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
    • Deprecated function: Return type of DatabaseStatementEmpty::valid() should either be compatible with Iterator::valid(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2348 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).
    • Deprecated function: Return type of DatabaseStatementEmpty::rewind() should either be compatible with Iterator::rewind(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 2348 of /var/www/webmd/apps/mdedge/htdocs/includes/database/database.inc).

    Stephen Hulkower, MD

    Article

    two medicine vials and a box

    Does XR injectable naltrexone prevent relapse as effectively as daily sublingual buprenorphine-naloxone?

    Author:
    Matthew Roe, MD
    Courtenay Gilmore Wilson, PharmD, BCPS, BCACP, CDE, CPP
    Carriedelle Wilson Fusco, FNP-BC
    Stephen Hulkower, MD
    Sue Stigleman, MLS

    EVIDENCE-BASED ANSWER: Yes. Monthly extended-release injectable naltrexone (XR-NTX) treats opioid use disorder as effectively as daily sublingual...

    • Read More

    Article

    Woman holding her knee in pain on a couch

    Which oral nonopioid agents are most effective for OA pain?

    Author:
    Benjamin Gilmer, MD, MS
    Stephen Hulkower, MD
    Courtenay Gilmore Wilson, PharmD, BCPS, BCACP, CDE, CPP
    Brittney Macdonald, MD
    Jonathan Pozner, MS4
    Sue Stigleman, MLS

    EVIDENCE-BASED ANSWER: Nonsteroidal anti-inflammatory drugs (NSAIDs), when used at the maximum clinically effective dose, reduce osteoarthritis (...

    • Read More

    Article

    How often does long-term PPI therapy cause clinically significant hypomagnesemia?

    How often does long-term PPI therapy cause clinically significant hypomagnesemia?

    Author:
    Timothy Plaut, MD
    Katelyn Graeme, DO
    Sue Stigleman, MLS
    Stephen Hulkower, MD
    Tasha Woodall, PharmD

    EVIDENCE-BASED ANSWER: Rarely. Proton pump inhibitors (PPIs) may be associated with decreases in serum magnesium laboratory...

    • Read More

    Article

    What are the benefits and risks of daily low-dose aspirin for primary prevention of CV events?

    Author:
    Justin Mutter, MD, MSc
    Rebecca Grandy, PharmD, BCACP, CPP
    Stephen Hulkower, MD
    Sue Stigleman, MLS

    EVIDENCE-BASED ANSWER: One nonfatal myocardial infarction (MI) will be avoided for every 126 to 138 adults who take daily aspirin for 10 years (...

    • Read More

    Article

    What is the best beta-blocker for systolic heart failure?

    Author:
    Stephen Hulkower, MD
    Benjamin A. Aiken, MD, MSPH
    Sue Stigleman, MLS

    EVIDENCE-BASED ANSWER: Three beta-blockers—carvedilol, metoprolol succinate, and bisoprolol—reduce mortality equally (by about 30% over one year)...

    • Read More

    Article

    Does surgery relieve the pain of a herniated disc?

    Author:
    Betsey Sorensen, MD
    Stephen Hulkower, MD
    Sue Stigleman, MLS

    EVIDENCE-BASED ANSWER: YES, in the short term. Patients with an acute episode of low back pain, radicular symptoms, and evidence of a herniated...

    • Read More

    Article

    What’s the best treatment for sebaceous cysts?

    Author:
    Brian R. Moore, MD
    Blake E. Fagan, MD
    Stephen Hulkower, MD
    Deborah C. Skolnik, MLS

    EVIDENCE-BASED ANSWER: Punch biopsy excision appears to be superior to traditional wide elliptical excision for the treatment of sebaceous cysts...

    • Read More

    Article

    Do preparticipation clinical exams reduce morbidity and mortality for athletes?

    Author:
    Stephen Hulkower, MD
    Blake Fagan, MD
    Jana Watts, MD
    Elizabeth Ketterman, MLS

    EVIDENCE-BASED ANSWER: Though clinical preparticipation exams (PPE) are recommended by experts and required in most states, we found no medium- or...

    • Read More

    Article

    Supraventricular Tachycardia Resistant to Treatment in a Pregnant Woman

    Author:
    Kevin Treakle, MD
    Barbara Kostic, PharmD
    Stephen Hulkower, MD
    • Read More

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