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Cochrane review: Trastuzumab benefit outweighs harm for advanced HER2-positive breast cancer
Key clinical point: Trastuzumab reduces breast cancer mortality by one-fifth, but the risk of heart toxicity is between three and four times more...
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Radiation exposure in children with heart disease highest for transplants
Key clinical point: Imaging radiation associated with heart transplants raises children’s lifetime cancer risk by 6.5%.Major finding: Children...
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Naloxegol cut opioid-associated constipation without impairing pain relief
Key clinical point: Naloxegol improves opioid-induced constipation without affecting pain relief.
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Undiagnosed joint hypermobility syndrome prevalent in GI clinics
Major finding: Joint hypermobility syndrome is significantly associated with gastrointestinal symptoms such as abdominal pain, bloating, and...
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Significant improvements in adherence, blood pressure, and LDL cholesterol with polypill
Major finding: A four-drug polypill significantly improves adherence, and reduces blood pressure and LDL cholesterol in patients with existing...
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Significant Improvements in Adherence, Blood Pressure, and LDL Cholesterol with Polypill
Major finding: A four-drug polypill significantly improves adherence, and reduces blood pressure and LDL cholesterol in patients with existing...
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Salt Targets Could Reduce Cardiovascular Disease Burden and Health Expenditures
Major finding: South African salt targets of less than 5 g/day could reduce cardiovascular mortality by 11% and significantly decrease out-of-...
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Salt targets could reduce cardiovascular disease burden and health expenditures
Major finding: South African salt targets of less than 5 g/day could reduce cardiovascular mortality by 11% and significantly decrease out-of-...
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No benefits to helmet therapy for positional skull deformation
Key clinical point: Watchful waiting may be best for infant positional skull deformity. Major finding: About a quarter (26%) of helmet-treated...
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Stress cardiac magnetic resonance feasible and prognostic in obese patients
Major finding: Obese individuals with no evidence of inducible ischemia or LGE in stress CMR are at significantly lower annualized risk of MACE (0...
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Validated patient-reported outcomes needed for inflammatory bowel disease
Key clinical point: Clinicians should begin to develop and use validated, self-administered questionnaires with items that are generated solely by...
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Drop in circumcision rates prompts call for Medicaid coverage
Major finding: Neonatal circumcision rates declined from 83% in 1960-1969 to 77% in 2010.Data source: Review including analysis of National Health...
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Adult dosing regimen of pegaspargase achieves high remission rates
Major finding: A dosing regimen of up to six intravenous 2,000 IU/m2-doses, given at 4-week intervals, achieved a 96% remission rate in adults...
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Cell-cycle inhibitor entinostat appeared to block azacitidine action
Major finding: The addition of cell-cycle inhibitor entinostat to a 10-day schedule of treatment with azacitidine led to a lower overall...